Obesity Medicine

Endocrinal Obesity

Obesity is associated with several endocrine diseases, including hypothyroidism and polycystic ovarian syndrome & rare ones as Cushing's syndrome, central hypothyroidism and hypothalamic disorders. The mechanisms for the development of obesity vary in according to the endocrine condition. Hypothyroidism is associated with accumulation of hyaluronic acid within various tissues, additional fluid retention due to reduced cardiac output and reduced thermogenesis. The pathophysiology of obesity associated with Polycystic Ovarian Syndrome remains complex as obesity, itself may simultaneously be the cause. Net excess of androgen appears to be pivotal in the development of central obesity. In Cushing's syndrome, an interaction with thyroid and growth hormones plays an important role in addition to an increased adipocyte differentiation and Adipogenesis.